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A known human carcinogen means there is sufficient evidence of a cause and effect relationship between exposure to the material and cancer in humans. Such determination requires evidence from epidemiologic (demographic and statistical), clinical, and/or tissue/cell studies involving humans who were exposed to the substance in question. Obviously, it is unethical to deliberately test potential carcinogens on humans, so "proving" something (in the rigorous scientific sense) to be a carcinogen in humans is a difficult, demanding and lengthy task!
Substances that are reasonably anticipated to be human carcinogens meet any of the following descriptions:
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A wide variety of information is required to assess carcinogenicity and risks to humans. For example, a substance may cause cancer in laboratory animals, but the mechanism by which this happens may not occur in humans.
The original 1986 and 1994 edition of OSHA's Hazardous Communication standard 1910.1200 (HCS 1994) relied on these three agencies for determining whether a chemical was a known or potential (reasonably anticipated to be a) human carcinogen:
Note: The "Registry of Toxic Effects of Chemical Substances" published by the National Institute for Occupational Safety and Health (NIOSH) indicated whether a chemical had been found by NTP or IARC to be a potential carcinogen.
The determination under the old system was absolute - if the material was listed as a carcinogen by these agencies, then that determination must be reflected in the employee training, labeling, and (material) safety data sheet.
The current edition of the HazCom Standard (HCS 2012) backs off somewhat on that absolute determination schema and expands the scope of the carcinogenicity determination. While a carcinogenic hazard classification must given to the material if it is listed under 29 CFR part 1910, subpart Z per Section A.6.4.2 and the SDS author has the option of relying on the IARC and NTP data to make the classification, the author is not required to automatically classify substances as carcinogens based solely on NTP or IARC data.
Instead, the current edition uses a broad evidence-based approach which is laid out in considerable detail in Section A.6 of Appendix A to HCS 2012. Under this new schema, substances are allocated into two categories based on the strength of the scientific evidence for carcinogenicity and then additional considerations based on human cancer potential. In theory, this cuts both ways, for example, a manufacturer could argue that because the human risk is low, an IARC-listed substance might not require a carcinogenic hazard classification. On the other hand, the new approach also gives the manufacturer the ability to state that their product should be considered carcinogenic in order to fully disclose a potential hazard they have become aware of (perhaps to shield them from legal liability, for example).
According to NIOSH's Publication No. 2010-145 (May 2010), past estimates that about 4% of cancer deaths in the U.S. are caused by occupational exposures have underestimated the actual rate. For example, exposures to carcinogens in the workplace may not result in cancer until 15-40 years later.
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According to the U.S. Section A.6.3 of Appendix A to HCS 2012, any mixture that has not been tested for carcinogenic properties is considered to be carcinogenic if it contains 0.1% or more of a carcinogenic substance. Section 11 (toxicological information) of the Safety Data Sheet will warn of any known carcinogenic properties.
Use extreme caution when working with carcinogenic (or potentially carcinogenic) materials in the workplace. Minimize your exposure and be sure to consult Section 8 (exposure controls/personal protection) of the SDS for the proper personal protective equipment (PPE) to protect yourself. Find alternative procedures or materials if possible; while these may cost a little more in up-front costs, the long term savings in disposal costs, litigation etc. usually more than make up for such an expense. Proper engineering controls and adminstrative controls are definitely required when working with carcinogens or potential carcinogens!
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See also: carcinoma, clastogen, mutagen, National Toxicology Program (NTP), teratogen.
Additional definitions from Google and OneLook.
Entry last updated: Saturday, May 21, 2022. This page is copyright 2000-2024 by ILPI. Unauthorized duplication or posting on other web sites is expressly prohibited. Send suggestions, comments, and new entry desires (include the URL if applicable) to us by email.
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