From: "Chance, Brandon" <bchance**At_Symbol_Here**MAIL.SMU.EDU>
Subject: Re: [DCHAS-L] Safer alternative to t-BuLi
Date: Wed, 17 Oct 2018 02:31:59 +0000
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Message-ID: A742BAE5-12B9-41EA-A052-F1DB0E4E2EB0**At_Symbol_Here**smu.edu
In-Reply-To


Margaret,

 

This research was more along the lines of a "proof of concept".  You are spot on that next steps would include creating a commercially viable version. 

 

Regards,

 

Brandon S. Chance, MS, CCHO

Director of Environmental Health and Safety

Sustainability Committee Chair

Office of Risk Management

Southern Methodist University 

PO Box 750231 | Dallas, TX  75275-0231

T) 214.768.2430 | M) 469-978-8664

bchance**At_Symbol_Here**smu.edu

 

"… our job in safety is to make the task happen, SAFELY; not to interfere with the work…" Neal Langerman

 

 

From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU> on behalf of Margaret Rakas <mrakas**At_Symbol_Here**SMITH.EDU>
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Date: Tuesday, October 16, 2018 at 7:37 AM
To: "DCHAS-L**At_Symbol_Here**PRINCETON.EDU" <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Subject: Re: [DCHAS-L] Safer alternative to t-BuLi

 

This paper looks highly promising, but here's the rub:  these safer solvents with reactive organometallic reagents need to become commercially available.  The authors added the safer solvents to commercial preparations, then removed the hexanes or whatever.  This isn't going to happen in the 'real world' laboratory and you still have the flammability issue while removing the higher-flammability solvent.

 

SO--is this something CHAS can push for with the major vendors/manufacturers of these reactive organometallic reagents??

 

Margaret

 

 

 

On Tue, Oct 16, 2018 at 4:41 AM, Chance, Brandon <bchance**At_Symbol_Here**mail.smu.edu> wrote:

 

Dear CHAS,

 

My old grad school advisor recently published a paper entitled "Safer solvents for reactive organometallic reagents" in Tetrahedron Letters.  It may be of some interest to those in  DCHAS.

 

https://www.sciencedirect.com/science/article/pii/S0040403918311316?via%3Dihub

 

 

Regards,

 

Brandon S. Chance, MS, CCHO

Director of Environmental Health and Safety

Sustainability Committee Chair

Office of Risk Management

Southern Methodist University 

PO Box 750231 | Dallas, TX  75275-0231

T) 214.768.2430 | M) 469-978-8664

 

"… our job in safety is to make the task happen, SAFELY; not to interfere with the work…" Neal Langerman

 

--- For more information about the DCHAS-L e-mail list, contact the Divisional membership chair at membership**At_Symbol_Here**dchas.org Follow us on Twitter **At_Symbol_Here**acsdchas



 

--

Margaret A. Rakas, Ph.D.
Manager, Inventory & Regulatory Affairs
Clark Science Center
413-585-3877 (p)

--- For more information about the DCHAS-L e-mail list, contact the Divisional membership chair at membership**At_Symbol_Here**dchas.org Follow us on Twitter **At_Symbol_Here**acsdchas

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