1. Is known to be so toxic to humans as to pose a hazard to health during transportation, or

2. In the absence of adequate data on human toxicity, is presumed to be toxic to humans because when tested on laboratory animals it has an LC₅₀ value of not more than 5000 ml/m³ ... LC50 values for mixtures may be determined using the formula in Sec. 173.133(b)(1)(i) of this subpart."

1. Is presumed to be toxic to humans because it falls within any one of the following categories when tested on laboratory animals (whenever possible, animal test data that has been reported in the chemical literature should be used):
   1. Oral Toxicity. A liquid with an LD₅₀ for acute oral toxicity of not more than 500 mg/kg or a solid with an LD₅₀for acute oral toxicity of not more than 200 mg/kg.

   2. Dermal Toxicity. A material with an LD₅₀for acute dermal toxicity of not more than 1000 mg/kg.

   3. Inhalation Toxicity

      1. A dust or mist with an LC₅₀ for acute toxicity on inhalation of not more than 10 mg/L; or

      2. A material with a saturated vapor concentration in air at 20 deg.C (68 deg.F) of more than one-fifth of the LC₅₀ for acute toxicity on inhalation of vapors and with an LC₅₀ for acute toxicity on inhalation of vapors of not more than 5000 ml/m³ or
2. Is an irritating material, with properties similar to tear gas, which causes extreme irritation, especially in confined spaces."

Books Available

NOTE: We may collect a share of sales or other compensation from the links in the following list:

• "A Textbook of Modern Toxicology, Fourth Edition", Hardcover, 672 pages, 2010. Estimated price $86.94. Info and/or order .
• "Toxicology Handbook, Third Edition", Paperback, 560 pages, 2015. Estimated price $67.97. Info and/or order.
• "Poisoning & Drug Overdose, Seventh Edition", Paperback, 960 pages, 2017. Estimated price $68.75. Info and/or order.
• "Small Animal Toxicology, Third Edition", Paperback, 928 pages, 2012. Estimated price $76.51. Info and/or order.
• "Pick Your Poison: How Our Mad Dash to Chemical Utopia is Making Lab Rats of Us All", Hardcover, 256 pages, 2011. Estimated price $23.55. Info and/or order ILPI recommended.

SDS Relevance

Be sure you're in compliance with DOT placards and labels from Safety Emporium.

Treat poisonous materials with respect! Read the Safety Data Sheet to find out what ways a poison can kill you -- is it by inhalation, ingestion and/or skin contact? What precautions should you take with the material? What kinds of personal protective equipment (PPE) are recommended?

Remember to read the material label and SDS if a poison is ingested. For example, it is often bad to induce vomiting because some materials can cause additional chemical burns to the throat and esophagus upon regurgitation. If in doubt, contact the nearest emergency room or call the American Association of Poison Control Centers poisoning emergency number (800) 222-1222.

Don't fool around with poisons. Treat them with great respect at all times.

Further Reading

• American Association of Poison Control Centers or, in an emergency, call (800) 222-1222.
• Poison Treatment in the Home from Pediatrics, 2003, 112(5), pp 1182-1185.
• OSHA's page on Chemical Hazards and Toxic Substances includes recognition, evaluation, controls, standards and more.
• Poisoning at the NIH's MedlinePlus.
• The National Toxicology Program.

See also: activated charcoal, antidote, catharsis, cytotoxin, emetic, mus (mouse), Swiss Poison Class, toxic

Additional definitions from Google and OneLook.

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