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Previous by Date: Subject: Chemical Safety headlines from Google Date: Fri, 14 Jan 2011 08:18:55 -0500 Author: Ralph Stuart

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Emergency crews also contacted the manufacturer, which informed them that there has never been a known case of someone being poisoned by the product.

"This particular poison, for human consumption, would have to be consumed in a much larger quantity to be toxic," Talmadge said.

               mg/kg.  For a 10 kg dog, this 
corresponds to 100 mg of pure
               Bromadiolone; that is, 2 kilos of bait at 
the dosage of
               0.005%.  =46rom 15 mg/kg on, hemorrhages begin to appear
               starting from the third day.  They are fatal unless we
               administer an intravenous injection of Vitamin K1 (5 
mg/kg of
               body weight).
               Chronic Toxicity - Daily dosages of 0.5 mg to 1 mg/kg 
which
               corresponds to 10 to 20 g of bait at the dosage of 0.005% 
of
               active material per kilo of body weight, cause no fatal
               reaction.  On the other hand, the ingestion of 200 
g of bait
               (10 mg/kg of active material) per kilo of body weight 
for
               several days can cause mortality.  This hazard 
is unrealistic,
               considering the total amount of bait that has to be 
consumed
               for several days.
      Cats:    The cat is more resistant than the dog.  The maximum 
tolerated
               oral dosage (MTD) stands at 25 mg/kg of active material, 
which
               represents, for an animal weighing 2 kgs., a 
consumption of
               one kilo of bait at 0.005%.
      Swine:   The tests were carried out with animals of an average 
weight
               of 25 kgs.
               The maximum tolerated dosage (MTD) for 5 days was 
25 mg of
               active material per day, per animal; that is, 500 gms. 
of bait
               at 0.005% of active material.
               There was no noticeable effect after a daily ingestion of 
10
               gms. of bait at 0.005% of active material for 45 days.
               No mortality was caused after two treatments of five days
               each, separated by an interval of 15 days' rest, of 
dosages
               corresponding to 125 gms., 250 gms., and 500 gms. of 
grains
               treated at 0.005% of active material.