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Date: Sat, 12 Jun 2010 07:18:59 -0400
Reply-To: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
Sender: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
From: Christopher Suznovich <snuz**At_Symbol_Here**MAC.COM>
Subject: Re: toxicity question
In-Reply-To: <F5D83326DC77FD4EA138E9194D6B28883371E835D5**At_Symbol_Here**DSMAILBOX.ad.uiuc.edu>
The toxicity difference between salt A and salt B will depend on how the the
activity of the drug differs between the 2 salts.
Example:
Very popular glucocorticoid steroid nasal spray. Initially manufactured as
the propionate salt but later introduced as the furoate salt. The furoate
salt allows the drug to better target the binding sites on the target cells
than propionate, therefore it is more effective and more potent and only 1/2
of the dosage it required for the furoate salt. Therefore since in this
case the toxicity of the drug would greatly differ due to the different
salt formulation.
Regards,
Chris
> From: "Tsiakals, Nicholas John"
> Reply-To: DCHAS-L Discussion List
> Date: Thu, 10 Jun 2010 16:30:45 -0500
> To:
> Subject: [DCHAS-L] toxicity question
>
> Good afternoon all,
>
> How does toxicity compare from one pharmaceutical salt to another? More
> specifically, is the toxicity of norepinephrine the same as norepinephrine
> bitartrate salt?
>
> Thanks,
> -Nick
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